摘要目的 探讨三维适形放疗(3D-CRT)联合多西他赛同步化疗治疗中晚期食管癌的疗效和安全性.方法 对96例中晚期食管癌患者采用3D-CRT治疗,95%PTV 66Gy/33次/6.6周,放疗第1天开始应用多西他赛25 mg/m2化疗,每周1次,按照恶性肿瘤近期疗效评价标准进行临床疗效评价.结果 完全缓解(CR)率为67.7%(65/96),部分缓解(PR)率为21.9%(21/96),无效10.4%(10/96),近期总有效率(CR+PR)为89.6%(86/96);随访1年、3年局部控制率分别为86.5%(83/96)、63.0%,1年、3年生存率分别为76.1%(73/96)和50.0%(48/96);主要不良反应为放射性食管炎83.3%(80/96)、血液学毒性52.1%(50/96).结论 3D-CRT联合多西他赛同步化疗对中晚期食管癌近期疗效较好.

abstractsObjective To evaluate the efficacy and toxicity of three dimensional confoimal radiotherapy(3D-CRT)concurrent taxotere for patients with esophageal carcinoma.Methods Ninty-six patients with esophageal carcinoma were received 3D-CRT concurrent taxotere,the radiotherapy was carried out by 3D-CRT,to a total dose 95% PTV 66Gy/33f/6.6W.The trial results were evaluated by the clinical curative effect criterion.Results Complete response rate(CR)was 67.7%.Overall response rate(CR+PR)was 89.6%.The local control rates of 1 year and 3 years were 86.5% and 63% ,respectively.The survival rates of 1 year and 3 years were 76.1% and 50.0%,respectively.The main acute toxic effect was radioactive esophagitis.Conclusions 3D-CRT concurrent taxotere could improve the overall response rate and survival rate of esophageal carcinoma.Although it increased the acute toxic effect,the patients could accept the therapy.