摘要目的 探讨四种药物治疗原发性高血压的经济成本与效果.方法 160例原发性高血压患者,随机分为贝那普利组40例、培哚普利组4J0例、氨氯地平组40例和尼群地平组40例,运用药物经济学的成本-效果分析进行评价.结果 四组降压总有效率比较,差异无统计学意义(均P>0.05);四组治疗前后症状总积分比较,差异均有统计学意义(均P<0.05);培哚普利费用低于贝那普利.结论 四种药物治疗原发性高血压疗效相似,但培哚普利费用低.

abstractsObjective To investigate the economic effects in patients with primary hypertension by four kinds of treatment.Methods 160 cases with primary hypertension were randomly divided into Benazepril group(n=40)、Perindopril group(n=40)、Amlodipine group(n=40) and Nitrendipine group(n=40),and data was evaluated with the pharmacoeconomic cost-effective analysis method.Results Hypertensive efficacy in 4 groups were not sig-nificantly different(x2=3.26,P>0.05);The symptom total score before treatment and after treatment was sisnifi-canfly different(a11 P<0.05);The SF-36 Scale after treatment in 4 groups were higher than before treatment(all P<0.05);The costs of pefindopril was lower than the benazepril.Conclusion Pharmacoeconomies played an important role in optimizing therapeutic scheme,guiding rational drug use and increasing economic effectiveness.