摘要目的 研究三氧化二砷(As2O3)对人胰腺癌细胞的抑制作用.方法 应用Cell Counting Kit-8法(CCK-8法)测定As2O3对人胰腺癌PC-3细胞株的抑制率,并与氟尿嘧啶(5-Fu)、吉西他滨(GEM)进行比较.结果 与5-Fu、GEM相比,As2O3抑瘤作用最强(P＜0.01或P＜0.05).结论 As2O3体外试验能有效抑制人胰腺癌PC-3细胞株的生长;As2O3对人胰腺癌PC-3细胞株生长的抑制作用强于5-Fu、GEM.As2O3较强的抗胰腺癌细胞能力可能与其广泛而独特的抗癌机制有关.

abstractsObjective To study the effects of arsenic trioxide ( As2 O3 ) on inhibiting the proliferation of pancreatic carcinoma cell lines. Methods The inhibiting rate of As2O3 and Fluorouracin(5-Fu) ,Gemcitabine(GEM) on pancreatic carcinoma cell lines PC-3 were detected by using CCK-8 assay. Results As compared with 5-Fu、GEM,the inhibiting rate of As2O3 was the highest one( P ＜ 0.01 or P ＜ 0.05). Conclusion As2O3 can inhibit pancreatic carcinoma cell lines PC-3 effectively in vitro. The effects of As2O3 on inhibiting the proliferation of pancreatic carcinoma cell lines was stronger than 5-Fu and GEM. This is possibly due to the extensive and unique anticancer mechanism of As2O3.