摘要目的 探讨复方去氧孕烯联合二甲双胍治疗青春期多囊卵巢综合征患者的临床疗效.方法 选择青春期多囊卵巢综合征患者120例,随机分为两组,A组60例单用复方去氧孕烯口服治疗,B组60例采用复方去氧孕烯联合二甲双胍口服治疗,用药时间均为3个疗程;比较两组用药前后的空腹胰岛素水平、空腹血糖、血清性激素水平的变化.结果 治疗前后两组性激素水平差异有统计学意义(P<0.01);两组用药前后空腹血糖均无变化;两组用药前后空腹血清胰岛素水平差异有统计学意义(P<0.05).结论 复方去氧孕烯联合二甲双胍治疗青春期多囊卵巢综合征能有效降低T、LH、LH/FSH,改善胰岛素抵抗,优于单药复方去氧孕烯治疗.

abstractsObjective To investigate the treatment of adolescent marvelon Metformin's clinical efficacy in patients with polycystic ovary syndrome.Methods 120 cases of adolescents with polycystic ovary syndrome were randomly divided into two groups,A group of 60 patients with single-agent oral therapy Marvelon, B group of 60 patients with Marvelon oral metformin therapy ,medication time was 3 courses; The levels of fasting insulin, fasting glucose, serum sex hormone levels were compared before and after treatment.Results The hormone levels in the two groups had significant difference before and after treatment (P <0.01) ;Two groups did not change in fasting blood glucose before and after treatment,no significant difference between the two groups(P >0.05) ;The insulin levels in two groups before and after treatment,was significantly different(P <0.05).Conclusion Metformin Marvelon adolescent polycystic ovary syndrome treatment can effectively reduce the T,LH,LH/FSH,insulin resistance,clinical results were satisfactory and better than single drug therapy Marvelon.