摘要目的 探讨早发冠心病患者的危险因素及冠状动脉的病变特征。方法 选择早发冠心病128例患者作为观察组，选择同期体检的健康人128例作为对照组，比较两组间的发病因素和冠状动脉的病变特征，分析相关因素。结果 两组BMI、高血压、吸烟、肥胖和家族史差异均有统计学意义（均P＜0.05）；观察组TC、TG、LDL-C、ApoB、Lp和Fib均较对照组升高（均P＜0.05）；观察组HDL-C和ApoA1均较对照组降低(均P＜0.05)。结论 家族史、高血压和血脂异常是早发冠心病的独立危险因素，吸烟对早发冠心病起重要作用；早发冠心病单支病变和左前降支病变较多见。

abstractsObjective To analyze risk factors and clinical manifestation of coronary lesions in patients with premature coronary artery disease.Methods 128 cases with premature coronary artery disease were selected as CAD group. 128 healthy persons were enrolled into control group from our hospital. The risk factors and clinical manifestation of coronary lesions in patients with premature coronary artery disease in two groups were compared. Results The risk factors of BMI ,hypertension,smoking,fat and familial history of coronary artery disease in two groups were significantly different ( P ＜ 0. 05 ). The levels of TC,TG, LDL-C, ApoB, Lp, Fib of the CAD group were higher than the control group. These factors of two groups were significantly different(P ＜0. 05). The levels of HDL-C and ApoA1 of the CAD group were lower than the control group. These factors of two groups were significantly different ( P ＜ O. 05 ).Conclusion Patients with premature CHD had many clinical cardiovascular risk factors. Preventing CHD to control the cardiovascular risk factor was important.