摘要目的：分析枸地氯雷他定递减疗法治疗慢性荨麻疹的临床疗效和不良反应。方法将162例慢性荨麻疹患者采用数字表法随机分为观察组和对照组，对照组给予枸地氯雷他定胶囊常规用药方法治疗，观察组给予枸地氯雷他定胶囊递减疗法进行治疗，比较两组疗效及对血清免疫球蛋白水平的影响。结果观察组总有效率为95．06％，与对照组总有效率（92．59％）比较差异无统计学意义（χ2＝3．254，P ＞0．05）；两组治疗后2周及治疗后4周 IgE 水平显著低于治疗前，差异均有统计学意义（t ＝8．291、7．931、6．936、5．152，均P ＜0．05），且观察组变化更为显著，组间差异有统计学意义（t ＝7．913、8．136，均 P ＜0．05）；两组治疗后症状评分显著低于治疗前，差异均有统计学意义（t ＝7．519、8．015，均 P ＜0．05），而组间比较差异无统计学意义（t ＝3．152、2．781，均 P ＞0．05）；观察组复发率为19．75％，显著低于对照组的40．74％，组间差异有统计学意义（χ2＝6．914，P ＜0．05）；两组不良反应发生率差异无统计学意义（χ2＝1．927，P ＞0．05）。结论对于慢性荨麻疹患者而言，应用枸地氯雷他定胶囊进行治疗不仅可获得较为有效的临床疗效，而且应用过程中毒副反应较小，同时递减疗法较常规用药方法可更加有效地降低血清 IgE 水平，故更值得在临床中推广使用。

abstractsObjective To analyze the clinical efficacy and adverse reactions of desloratadine citrate decre-mental therapy in treatment of chronic urticaria.Methods 162 cases of patients with chronic urticaria were selected, they were randomly divided into observation group and control group.Control group was given routine treatment of desloratadine citrate capsule,while the observation group was given desloratadine citrate capsule decreasing therapy, the therapeutic effect and the levels of serum immunoglobulins were compared between the two groups.Results After treatment,the total effective rate of the observation group was 95.06%,there was no significant difference compared with 92.59% of the control group (χ2 =3.254,P >0.05);Two weeks and four weeks after treatment,IgE levels were significantly lower than before treatment,there were significant difference (t =8.291,7.931,6.936,5.152,all P <0.05),and the observation group change was more significant,the differences between the two groups were statistically significant (t =7.913,8.136,all P <0.05).After treatment symptom score was significantly lower than before treat-ment,and there were significant difference (t =7.519,8.015,all P <0.05),but the differences between groups were not significant (t =3.152,2.781,all P >0.05).The recurrence rate in the treatment group was 19.75%,which was significantly lower than the 40.74% of the control group,the difference between the two groups was statistically signif-icant (χ2 =6.914,P <0.05).But there was no significant difference in the incidence of adverse reactions between the two groups (χ2 =1.927,P >0.05).Conclusion Desloratadine citrate capsules in treatment of chronic urticaria can not only obtain more effective clinical curative effect,but also has less toxic side effect.For the purposes of the application method of the drug,decreasing method compared with conventional medication therapy can effectively improve the level of serum IgE.Therefore,it is worthy of clinical application.