摘要目的 探讨补肾活血化痰中药对颈动脉狭窄患者血脂及同型半胱氨酸(Hcy)水平的影响.方法 选取颈动脉狭窄患者120例,采用权重系数对患者的证型进行分析,分为痰浊证、血瘀证、阴虚证和气.虚证,并采用补肾活血化痰中药对患者进行治疗.治疗前后分别应用酶转换法及酶重复法检测患者的血脂及Hcy水平.结果 经过权重法分析,痰浊证患者最多,占90.0％ (108/120),其次血瘀证患者占82.5％(99/120),阴虚证患者占67.5％ (81/120),而气虚证患者占51.67％ (62/120).治疗前,痰浊证、血瘀证、阴虚证和气虚证患者Hcy、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)水平呈递增趋势;治疗后,痰浊证Hcy、TC、TG、HDL分别为(10.38±0.12) μmol/L、(7.23±0.91)mmol/L、(11.03±0.13) mmol/L、(7.30±0.84) mmol/L,血瘀证Hcy、TC、TG、HDL分别为(6.39±0.22) μmol/L、(3.21±0.62) mmol/L、(6.45±0.20)mmol/L、(3.21±0.62) mmol/L,阴虚证Hcy、TC、TG、HDL分别为(16.37±0.21) μmol/L、(10.22±0.88) mmol/L、(15.89±0.19) mmol/L、(10.67±0.65) mmol/L,气虚证Hcy、TC、TG、HDL分别为(10.25±0.41) μmol/L、(8.20±0.73) mmo]/L、(9.98±0.11) mmol/L、(8.43± 0.34) mmol/L,治疗后各证型Hcy、TC、TG、HDL均显著改善,治疗前后差异均有统计学意义(F=46.774、12.310、49.486、59.406,均P＜0.05).结论 补肾活血化痰中药治疗颈动脉狭窄患者的疗效显著,可显著改善Hcy、TC、TG、HDL水平.

abstractsObjective To investigate the effect of Bushen Huoxue Huatan decoction on blood lipid and homocysteine (Hcy) levels of patients with carotid artery stenosis.Methods 120 cases of carotid artery stenosis were selected.The different syndromes of patients were analyzed by weight coefficient,including phlegm turbidity,blood stasis,yin deficiency and qi deficiency syndrome.Phlegm traditional Chinese medicine was used to treat the patients.Serum lipids and Hcy levels before and after treatment were measured with enzyme conversion method and enzyme repeat method.Results After weight coefficient analysis,90.0％ (108/120) of patients were phlegm turbidity syndrome,82.5 ％ (99/120) were blood stasis,yin deficiency was 67.5 ％ (81/120) and qi deficiency syndrome was 51.67％ (62/120).Before treatment,the Hcy,TC,TG and HDL levels of patients with phlegm turbidity,blood stasis,yin deficiency and qi deficiency syndrome were increased.After treatment,the Hcy,TC,TG and HDL levels of patients with phlegm turbidity were (10.38 ± 0.12) μmol/L,(7.23 ± 0.91) mmol/L,(11.03 ± 0.13) mmol/L,(7.30 ±0.84) mmol/L,respectively,which of patients with blood stasis were (6.39 ± 0.22) μ mol/L,(16.37 ± 0.21) μmol/L,(6.45 ±0.20) mmol/L and (3.21 ±0.62)mmol/L,respectively,which of patients with yin deficiency were (16.37 ± 0.21) mmol/L,(10.22 ± 0.88) mmol/L,(15.89 ± 0.19) mmol/L,(10.67 ± 0.65) mmol/L,respectively,which of patients with qi deficiency were (10.25 ± 0.14) mmol/L,(8.20 ± 0.73) mmol/L,(9.98 ± 0.11) mmol/L,(8.43 ± 0.34) mmol/L,respectively.After treatment,the levels of Hcy,TC,TG and HDL were significantly improved,and the differences were statistically significant(F =46.774,12.310,49.486,59.406,all P ＜ 0.05).Conclusion Bushen Huoxue Huatan decoction is effective in the treatment of carotid artery stenosis,which can significantly improve the levels of Hcy,TC,TG and HDL,and it is of great value.