摘要目的 探讨艾司西酞普兰治疗中老年抑郁伴失眠患者的临床疗效及安全性.方法 选取中老年抑郁伴失眠患者60例,采用随机数字表法分为观察组和对照组,每组30例.对照组采用西酞普兰治疗,观察组采用艾司西酞普兰治疗,两组患者均治疗8周.治疗前后应用汉密尔顿抑郁量表(HAMD)及匹兹堡睡眠质量指数量表(PSQI)对患者的抑郁程度及睡眠质量进行评分,比较两组不良反应发生率及临床总有效率.结果 与治疗前比较,观察组和对照组HAMD评分分别由(26.76±3.47)分和(26.53±3.44)分降低至(13.48±1.36)分和(18.25±2.15)分;PSQI评分分别由(13.26±1.60)分和(13.31±1.64)分降低至(7.24±1.01)分和(9.47±1.22)分,两组治疗前后差异均有统计学意义(均P＜0.05);治疗结束后,观察组HAMD评分(t=10.270,P=0.000)及PSQI评分(t=-7.712,P=0.000)显著低于对照组;两组不良反应发生率差异无统计学意义(x2=0.425,P=0.935);两组总有效率差异无统计学意义(x2=2.785,P=0.426).结论 艾司西酞普兰能够改善中老年抑郁伴失眠患者的抑郁情绪,提高睡眠质量,且安全性高.

abstractsObjective To investigate the clinical efficacy and safety of escitalopram in the treatment of depressed elderly patients with insomnia.Methods According to the digital table,60 depressed elderly patients with insomnia were selected and randomly divided into the control group and the observation group,30 cases in each group.The control group was treated by citalopram,the observation group was treated by escitalopram,the two groups were treated for 8 weeks.The depression and sleep quality were tested by HAMD and PSQI before and after treatment,and the incidence of adverse reactions and the total clinical efficacy were compared between the two groups in the same time.Results Compared with pre-treatment,the HAMD scores in the control group and observation group were decreased from (26.76 ± 3.47) points and (26.53 ± 3.44) points to (13.48 ± 1.36) points and (18.25 ± 2.15) points respectively;the PSQI scores were decreased from (26.76 ± 3.47) points and (26.53 ± 3.44) points to (13.48 ± 1.36)points and (18.25 ± 2.15)points respectively,and the differences were statistically significant(all P ＜ 0.05).After treatment,compared with the control group,the HAMD score (t =10.270,P =0.000) and PSQI score (t =-7.712,P =0.000) in the observation group were significantly lower.The incidence rate of adverse effects was lower (x2 =0.425,P =0.935) and the total effective rate was higher,but without statistically significant differences(x2 =2.785,P =0.426).Conclusion Escitalopram can improve the depression of elderly depression patients with insomnia,improve sleep quality with high safety.