摘要目的 分析阿立哌唑联合碳酸锂治疗急性躁狂症的临床效果.方法 从2016年1月至2017年1月收治的急性躁狂症患者中选取72例患者纳入研究,按照入院顺序,单号作为对照组(n=36),双号作为观察组(n=36),对照组给予氯氮平联合碳酸锂治疗,观察组采用阿立哌唑联合碳酸锂治疗,通过BRMS评分、治疗有效率、不良反应发生率等指标评估治疗方案的安全性和有效性.结果 治疗1周、2周时,观察组BRMS评分分别为(21.23±2.22)分与(20.02±2.12)分,低于对照组相应指标(t=4.0390、4.0025,均P<0.05),治疗4、8周两组BRMS评分接近;观察组治疗有效率为94.44%,与对照组的治疗有效率91.67%比较,差异无统计学意义(P>0.05);观察组不良反应发生率19.44%,明显低于对照组的41.67%,差异有统计学意义(χ2=11.6446,P<0.05).结论 阿立哌唑联合碳酸锂及氯氮平联合碳酸锂治疗急性躁狂症疗效相当,但阿立哌唑联合碳酸锂起效快,可有效缓解疾病症状,且不良反应少,安全性高,可在临床积极推广和应用.

abstractsObjective To study the clinical effect of aripiprazole combined with lithium carbonate in the treatment of acute mania .Methods 72 patients with acute mania were selected in this research .According to the order of admission,the patients with odd numbers were selected as the control group (n=36),and the patients with even numbers were selected as the observation group (n=36).The control group was treated with clozapine combined with lithium carbonate ,the observation group was treated by aripiprazole combined with lithium carbonate .The safety and efficacy of the treatment were evaluated by BRMS score , effective rate , incidence rate of adverse reaction etc .Results After treatment for 1 week,2 weeks,the BRMS scores of the observation group were (21.23 ±2.22)points and (20.02 ±2.12)points,which were significantly lower than those of the control group (t=4.0390,4.0025,all P<0.05).After treatment for 4 and 8 weeks,the BRMS scores of the two groups were similar .The effective rate of the observation group was 94.44%,which of the control group was 91.67%,the difference was not statistically signifi-cant (P>0.05).The incidence rate of adverse reactions of the observation group was 19.44%,which was significantly lower than 41.67% of the control group,the difference was statistically significant (χ2 =11.6446,P<0.05) .Conclusion Aripiprazole combined with lithium carbonate has similar effect with clozapine combined with lithium carbonate in the treatment of acute mania ,but the combination therapy of aripiprazole and lithium carbonate can effec -tively alleviate the symptoms of the disease ,and with less adverse reaction ,high safety,which can be promoted and applicated in clinical .