摘要目的 探讨C-反应蛋白(C-reactive protein,CRP)联合凝血酶原时间(Prothrombin time,PT)、活化部分凝血酶时间(Activated partial thromboplastin time,APTT)对于新生儿晚发型败血症的诊断价值.方法 收集2013年1月至2018年1月丽水市妇幼保健院新生儿科收治的100例败血症患儿作为研究对象,根据血培养的结果,将血培养阳性患儿归为败血症A组(53例),血培养阴性患儿归为败血症B组(47例),另选取同期出生的50例正常新生儿归入对照组.检测并比较3组受试对象CRP、PT和APTT值;绘制受试者工作曲线(receiver-operating characteristic curves,ROC),计算各检测指标ROC曲线下面积(area under ROC curve,AUC)以及灵敏度、特异度、阳性预测值和阴性预测值,用二项分类Logistic回归法建立新的变量CPR+ PT+ APTT,继续绘制ROC曲线,计算新变量的AUC、灵敏度、特异度、阳性预测值和阴性预测值.结果对照组、败血症A组、败血症B组的CPR、PT和APTT实验室检测结果均依次升高(F=10.616、6.155、5.243,P=0.000、0.000、0.000),差异具有统计学意义.4项指标中,CPR+ PT+ APTT的AUC最高(0.94),灵敏度最高(93.42％),特异度最高(91.66％),阳性预测值最高(92.60％),阴性预测值最大(78.55％).结论 在血培养未能及时诊断新生儿晚发型败血症的情况下,联合检测CPR+ PT+ APTT,可以为其早期诊断提供某些线索,值得临床关注.

abstractsObjective To investigate the clinical value of C-reactive protein (CRP) combined with prothrombin time (PT) and partially activated thromboplastin time (APTY) in the diagnosis of neonatal late-onset sepsis.Methods From January 2013 to January 2018,100 neonates with sepsis admitted to our department of neonatology in Lishui Maternal and Child Health-Care Center were collected.According to the results of blood culture,neonates with positive blood culture were classified as sepsis group A (53 cases),and neonates with negative blood culture were classified as sepsis group B (47 cases).Another 50 normal newborns born at the same period were included in the control group.The CRP,PT and APTT values of the three groups were detected and compared.The receiver-operating characteristic curves (ROC) were plotted to obtain the area under ROC curve (AUC) and the sensitivity,specificity,positive predictive value and negative predictive value.Another ROC curve was plotted to obtain the area under ROC curve (AUC) and the sensitivity,specificity,positive predictive value,and negative predictive value for a new variable,CPR + PT + APTT,which was established using a binomial logistic regression method.Results The results of CPR,PT and APTT in the control group,sepsis group A and sepsis group B all increased in turn (F=10.616,6.155,5.243,P =0.000,0.000,0.000).CPR + PT + APTT had the largest AUC (0.94),the highest sensitivity (93.42％),the highest specificity (91.66％),the highest positive predictive value (92.60％),and the highest negative predictive value (78.55％) in the four indicators.Conclusion When blood culture fails to diagnose late-onset neonatal sepsis,combined detection of CPR + PT + APTT can provide some clues for its early diagnosis,which is worthy of clinical attention.