摘要观察艾司西酞普兰治疗伴抑郁症状的酒精依赖患者的临床效果及其对社会功能恢复的影响.方法 选择温州市第七人民医院2016 年1 月至2017 年12 月收治的伴抑郁症状的酒精依赖患者80例为观察对象,采用随机数字表法分为两组,观察组40例应用艾司西酞普兰治疗,对照组40例应用安慰剂治疗,两组疗程均为2个月.比较两组患者的抑郁评分、社会功能缺陷筛选量表评分、生活质量评分及不良反应发生率.结果 观察组治疗1个月、治疗2个月抑郁评分分别为(15.02 ±2.23)分、(9.02 ±2.12)分,均低于对照组的(20.13 ±2.12)分、(15.24 ±2.15)分(t＝10.504、13.029,均P＜0.05);观察组治疗1个月、治疗2个月社会功能缺陷筛选量表评分分别为(2.85 ±1.23)分、(0.89 ±0.52)分,均低于对照组的(4.13 ± 1.62)分、(2.52 ±1.16)分(t＝3.930、8.110,均P＜0.05);观察组患者治疗后躯体健康、心理健康、物质生活、社会功能及总生活质量评分分别为(87.47 ±5.69)分、(84.63 ±5.21)分、(87.16 ±5.24)分、(85.46 ±5.95)分、(86.12 ±5.95)分,均高于对照组的(79.58 ±5.93)分、(76.72 ±7.82)分、(79.28 ±5.57)分、(75.92 ±5.45)分、(78.46 ±5.85)分(t＝5.995、5.257、6.435、7.384、5.733,均P＜0.05);两组不良反应发生率差异无统计学意义(P＞0.05).结论 对伴抑郁症状的酒精依赖患者应用艾司西酞普兰治疗具有较好的效果,不仅有助于改善抑郁状况,还有助于促进患者社会功能恢复,且安全性较高.

abstractsObjective To observe the clinical effect of escitalopram in the treatment of alcohol -dependent patients with depressive symptoms and its influence on social function recovery .Methods From January 2016 to December 2017,80 alcohol -dependent patients with depressive symptoms in the Seventh People ＇s Hospital of Wenzhou were selected and divided into two groups by random digital table method ,with 40 cases in each group.The observation group was treated with escitalopram.The control group was treated with placebo for 2 months.The scores of depression,social dysfunction screening scale , quality of life and incidence of adverse reactions were compared between the two groups.Results After treatment for 1 month and 2 months,the depression scores of the observation group were (15.02 ±2.23)points and (9.02 ±2.12)points,respectively,which were lower than those of the control group[(20.13 ±2.12) points,(15.24 ±2.15) points] ( t ＝10.504,13.029,all P ＜0.05).After treatment for 1 month and 2 months,the scores of the screening scale for social functional defects in the observation group were (2.85 ±1.23)points and (0.89 ±0.52)points,respectively,which were lower than those in the control group [(4.13 ± 1.62)points,(2.52 ±1.16)points]( t＝3.930,8.110,all P＜0.05).The scores of physical health ,mental health, physical life,social function and total quality of life in the observation group were (87.47 ±5.69) points,(84.63 ± 5.21)points,(87.16 ±5.24) points,(85.46 ±5.95) points and (86.12 ±5.95) points,respectively,which were higher than those of the control group [(79.58 ±5.93)points,(76.72 ±7.82)points,(79.28 ±5.57)points,(75.92 ± 5.45) points,(78.46 ±5.85) points] (t＝5.995,5.257,6.435,7.384,5.733,all P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Escitalopram in the treatment of alcohol -dependent patients with depressive symptoms has good effect ,not only helps to improve the depression,but also helps to promote the recovery of social function of the patients ,and the safety is relatively high.