摘要目的:探讨系统性自身免疫性疾病（SADs）患者抗心磷脂抗体（aCL）和抗β 2糖蛋白Ⅰ抗体（aβ 2GPI）与缺血性脑卒中（IS）的相关性。 方法:选取川北医学院附属医院2019年1-12月诊治的SADs患者104例，依据是否合并IS分为两组：合并IS的SADs患者42例为病例组（IS组），未合并IS的SADs患者62例为对照组（non-IS组）。定性比较IS组与non-IS组抗磷脂抗体（aPLs）阳性率，定量比较两组aCL、aβ 2GPI表达水平的差异，并采用logistic回归分析评估SADs患者罹患IS的危险因素。 结果:IS组aPLs阳性率为61.9%（26/42），明显高于non-IS组的40.3%（25/62），差异有统计学意义（χ 2=4.66， P=0.031）。IS组aCL-IgM、aβ 2GPI-IgM分别为（22.82±27.27）RU/mL、（18.70±23.95）RU/mL，均明显高于non-IS组的（13.34±8.43）RU/mL、（7.61±5.80）RU/mL，差异均有统计学意义（ t=-2.18、-2.76， P=0.034、0.009）。logistic回归分析结果显示，aPLs是IS发生的独立危险因素（ P=0.037）。 结论:aCL和aβ 2GPI与SADs患者IS发生有密切联系，是SADs患者发生IS的独立危险因素。

abstractsObjective:To correlate anti-cardiolipin antibody (aCL) and anti-β2 glycoprotein I antibody (aβ2GPI) with ischemic stroke (IS) in patients with systemic autoimmune diseases (SADs).Methods:A total of 104 patients with SADs who received treatment in the Affiliated Hospital of North Sichuan Medical College during January to December 2019 were included in this study. They were divided into two groups whether they had IS (IS group, n = 42) or not (non-IS group, n = 62). aPL positive rate was qualitatively compared between the IS and non-IS groups. aCL and aβ2GPI expression levels were quantitatively compared between the IS and non-IS groups. Logistic regression analysis was performed to evaluate the risk factors for IS in patients with SADs. Results:aPL positive rate in the IS group was significantly higher than that in the non-IS group [61.9% (26/42) vs. 40.3% (25 /62), χ2 = 4.66, P = 0.031]. The aCL-IgM and aβ2GPI-IgM levels in the IS group were (22.82 ± 27.27) RU/mL and (18.70 ± 23.95) RU/mL, respectively, which were significantly higher than those in the non-IS group [(13.34 ± 8.43) RU/mL, (7.61± 5.80) RU/mL, t = -2.18, -2.76, P = 0.034, 0.009]. Logistic regression analysis showed that aPL is an independent risk factor for IS ( P = 0.037). Conclusion:aCL and aβ2GPI are closely related to the occurrence of IS and are the independent risk factors for IS in patients with SADs.