摘要目的:探讨多元叠加整合声治疗主观性耳鸣疗效的影响因素。方法:选择2019年6月至2020年6月厦门大学附属第一医院收治的主观性耳鸣患者431例为研究对象，采用横断面研究方法，采用多元叠加整合声治疗（T-MIST）验配平台对耳鸣患者进行精细化检测，并采用耳鸣残疾量表评估耳鸣患者的严重程度，结合患者的基本特征，采用SPSS软件分析影响主观性耳鸣患者多元叠加整合声治疗效果的因素。结果:多因素logistic回归分析结果显示，相对于短期耳鸣患者，病程为3～12个月的患者 OR（95% CI）=1.982（1.033~3.804）， P=0.040；病程为 > 12个月的患者 OR（95% CI）=2.411（1.322~4.396）， P=0.004；随着耳鸣残疾量表（THI）评分的增高，T-MIST的治疗效果越好［ OR（95% CI）=1.014（1.004~1.024）， P=0.007］；听力补偿有效组的T-MIST治疗效果更好［ OR（95% CI）=0.133（0.081~0.216）， P < 0.001］。 结论:病程长短、THI水平、听力补偿有效为多元叠加整合声治疗效果的影响因素，可为主观性耳鸣患者治疗提供依据。

abstractsObjective:To investigate the influential factors of the efficacy of tinnitus multivariate integrated sound therapy (T-MIST) in the treatment of subjective tinnitus.Methods:A total of 431 patients with subjective tinnitus who received treatment in The First Affiliated Hospital of Xiamen University from June 2019 to June 2020 were included in this study. A cross-sectional study method was used to conduct refined testing on tinnitus patients using the T-MIST matching platform. The severity of tinnitus patients was evaluated using the Tinnitus handicap inventory scale. SPSS software was used to analyze the factors affecting the effectiveness of the T-MIST for subjective tinnitus based on patients' basic characteristics.Results:Multivariate logistic regression analysis showed that compared with patients with short-term tinnitus, OR (95% CI) was 1.982 (1.033-3.804), P = 0.040, in patients with 3-12 months of disease duration, OR (95% CI) was 2.411 (1.322-4.396), P = 0.004 in patients with > 12 months of disease duration. With the increase in tinnitus handicap inventory score, the efficacy of T-MIST became better [ OR (95% CI) = 1.014 (1.004-1.024), P = 0.007]. The efficacy of T-MIST was better in the hearing compensation-effective patients [ OR (95% CI) = 0.133 (0.081-0.216), P < 0.001]. Conclusion:The course of the disease, tinnitus handicap inventory score, and effective hearing compensation are the influential factors of T-MIST. They can provide evidence for the treatment of subjective tinnitus.