摘要生长刺激表达基因2蛋白（ST2）是白细胞介素（IL）-1受体家族的一员，主要分为可溶性ST2（sST2）和跨模型ST2（ST2L），sST2是一种诱饵受体，竞争性与IL-33结合阻断IL-33/ST2L信号传导通路，促进心肌肥厚、心肌纤维化和心室功能障碍。测定sST2对心血管疾病的诊断和/或预后判定具有重要价值。本文主要对心力衰竭、冠心病、高血压、心房颤动、心肌炎、心肌病、急性主动脉夹层、肺动脉高压等心血管疾病与sST2关系的研究进展进行综述。

abstractsGrowth stimulating gene 2 (ST2) protein is a member of the interleukin-1 receptor family. It is mainly divided into a soluble secreted form sST2 and a transmembrane form ST2L. sST2 is a decoy receptor that competitively binds to interleukin-33 to block the interleukin-33/ST2L signaling pathway, worsening myocardial hypertrophy, fibrosis, and ventricular dysfunction. Measuring sST2 is of important value for diagnosis and/or prognosis evaluation of cardiovascular diseases. This paper mainly reviews the research progress in the relationship between cardiovascular diseases such as heart failure, coronary heart disease, hypertension, atrial fibrillation, myocarditis, cardiomyopathy, acute aortic dissection, and pulmonary hypertension, and sST2.