摘要The identification of specific survival-related differentially expressed genes (DEGs) is a method for uncovering therapeutic approaches for various cancers, including glioma. However, the key target genes associated with the occur-rence and development of gliomas remain unknown. In this study, we performed bioinformatics analysis on 17 GSE data-sets and identified DEGs correlated with glioma. A total of 74 mutual-DEGs with downregulated expression in gliomas compared with that in normal brain tissues were found in 17 datasets. These DEGs were related to GABAergic synaptic transmission, chloride transmembrane transport, glutamate secretion, and gamma-aminobutyric acid signaling pathway. Gamma-aminobutyric acid type A receptor subunit gamma 2 (GABRG2) was identified as a hub gene in the protein-pro-tein interaction network. GABRG2 exhibited lower expression in IDH wild-type astrocytoma than that in IDH mutant as-trocytoma and indicated poor prognosis in glioma patients. GABRG2 may contribute to the progression of glioma by af-fecting GABA receptor-related pathways and is a potential biomarker for the diagnosis and treatment of glioma.