摘要目的 观察普贝生、米索前列醇、缩宫素三种促进官颈成熟药物的有效性和安全性.方法 采用随机对照研究方法,将180例初产妇分为3组,A组:普贝生;B组:小剂量米索前列醇组;C组:缩宫素组.比较三组用药前、后4、8、12 h官颈Bishop评分,用药后分娩情况、胎儿窘迫及新生儿窒息的发生率.结果 A、B、C三组的有效率分别为88.3%、85.0%、35.0%;用药后剖宫产率分别为21.7%、25.0%、60.0%.A,B组分别与C组比较差异有统计学意义(P＜0.05).结论 普贝生及米索前列醇均是安全、有效的,临床应用成功率高;缩宫素则疗效欠佳.

abstractsObjective To observe the efficacy and safety of three drugs(dinoprostone suppositories,misopmstol and oxytocin) to promote cervieal ripening.Methods A randomized control study method was used.The 180 primipara was divided into 3 groups.Group A:dinoprostone suppositories,Group B:low-dose misoprostol,Group C:oxytocin.The maternal cervical Bishop score of three drugs being used before and after 4,8,12 h was compared between the three groups,as well as the labor situation,the rate of fetal distress and neonatal asphyxia after the drugs.Results The effective rates of groups A,B,C were 88.3%,85.0%,35.0%.The cesarean section rates of three groups were 21.7%,25.0%,60.0%.There was significantly different between groups A,B with group C(P＜0.05).Conclusion Dinoprostone suppositories and misoprostol were safe and effective,and they had a high success rate of clinical application.Then Oxytocin was ill effect.