摘要目的 探讨二甲双胍联合罗格列酮治疗多囊卵巢综合征(PCOS)合并高胰岛素血症的临床效果.方法 给予36例PCOS合并高胰岛素血症患者二甲双胍500 mg,3次/d,罗格列酮4 mg,1次/d治疗,对治疗前及治疗后12周、24周血清胰岛素、血糖、胰岛素抵抗指数、性激素水平及体重指数进行检测.结果 二甲双胍联合罗格列酮治疗可降低血清空腹胰岛素、睾酮、黄体生成素、体重指数水平(P<0.0 5),提高胰岛素敏感性.结论 二甲双胍联合罗格列酮是治疗多囊卵巢综合征合并高胰岛素血症的有效方法.

abstractsObjective To investigate the clinical effects of Rosiglitazone and Mefformin in the treat-ment of the polycystic ovary syndrome (PCOS) patients with hyperinsulinemia. Methods Thirty-six PCOS women with hyperinsulinemia participated in the study and were administered with Mefformin at a dose of 500 mg three times a day and Rosiglitazone 4 mg one time a day. Serum insulin, glucose, HOMA-IR, sex hormones and BMI were evaluated before and then after a 12 week and 24 week therapy. Results After treatment,fasting insulin, testosterone, LH and BMI level decreased (P<0.05). Conclusion Rosiglitazone and Metformin is an effective management in therapy of PCOS patients with hyperinsulinemia.