摘要目的 探讨脂蛋白a与动脉粥样硬化性肾动脉狭窄(ARAS)的关联性.方法 以“atherosclerotic renal artery stenosis”为检索词,检索PubMed和EMBASE数据库2010年之前的文献；以“肾动脉狭窄”与“脂蛋白”为检索词,检索万方、中国知网(CNKI)及维普数据库2010年之前的文献.根据制定的标准对文献筛选后,采用Newcastle-Ottawa量表对纳入的病例对照研究和队列研究的质量进行评价,用Review Manager 5.0软件进行荟萃分析,研究脂蛋白a与ARAS的关联性.结果 共有5篇文献符合入选标准,合计661例患者.Meta分析结果显示:病例组的脂蛋白a水平比对照组高0.0702 g/L,95％置信区间为(-0.0688,0.2092),脂蛋白a水平在病例组和对照组之间的差异无统计学意义(P=0.32).结论 根据现有的研究,尚无法证实脂蛋白a水平升高与ARAS之间的关联性.

abstractsObjective To explore the relevance between lipoprotein(a) and atherosclerotic renal artery stenosis in adults.Methods Literature search was conducted in PubMed and EMBASE Database,using “atherosclerotic renal artery stenosis” as the search term as well as in Wanfang Database,China National Knowledge Infrastructure,and Cqvip Database,using “renal artery stenosis” and “lipoprotein” as the search terms,aiming to find case-control or cohort studies published before 2010.The qualities of all the literatures enrolled were evaluated using Newcastle-Ottawa scale and the data from which were analyzed by the Review Manager 5.0 software.Results Five eligible case-control studies (661 cases) entered the Meta analysis.The results showed that the lipoprotein(a) level was not significantly higher in the case group than that in the control group [ mean difference =0.0702 g/L,95％ CI ( - 0.0688,0.2092),P =0.32 ].Conclusion According to the existing studies,the relevance between lipoprotein(a) and atherosclerotic renal artery stenosis can not be established.