摘要Parkinson's disease(PD)is a neurodegenerative disorder characterized by the aggregation of α-synuclein(α-syn)and dysregulated synaptic vesicle(SV)recycling.Emerging evidence suggests that ferroptosis is the target of PD therapy.However,the identification of effective anti-ferroptosis treatments remains elusive.This study explores the therapeutic potential of low-intensity ultrasound(US)in modulating SV recycling and anti-ferroptosis in cellular and animal models of PD.We demonstrate that optimized US stimulation(610 kHz,0.2 W/cm2)activates Piezo1 channel-mediated fast endophilin-mediated endocytosis,which pro-motes SV recycling and synaptic function,presenting with increased frequency and amplitude of both spontaneous excitatory synaptic currents and miniature excitatory post-synaptic currents.Repaired SV recycling in turn reduces the accumulation of α-syn expression and ferroptotic cell death.These findings support the potential of noninvasive ultra-sonic neuromodulation as a therapeutic strategy for PD and lead to meaningful health outcomes for the aging population.