换一批
换一批A combination of chondroitinase ABC, glial cell line-derived neurotrophic factor, and Nogo A antibody delayed-release microspheres for the treatment of spinal cord injury
摘要The purpose of this study was to evaluate the effect of poly(lactide-co-glycolic acid) delayed-release microspheres, which were prepared using glial cell line-derived neurotrophic factor (GDNF), on the delayed-release, controllability, and protection of GDNF activity. The present study is the first to combine chondroitinase ABC, GDNF, and Nogo A antibody delayed-release microspheres for the treatment of spinal cord injury. Results show that the combined therapy of chondroitinase ABC,GDNF, and Nogo A antibody microspheres can increase the immunoreaction of neurofilament 200in the injured spinal cord, and this therapeutic effect was better than chondroitinase ABC, GDNF, or Nogo A antibody microspheres administered singularly.
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关键词
glial cell line-derived neurotrophic factormicrospherespoly(lactide-co-glycolic acid)spinal cord injuryneural regeneration
分类号
R651.2
栏目名称
Stem cells and Neuroregeneration
DOI
10.3969/j.issn.1673-5374.2011.10.009
发布时间
2011-07-04
基金项目
the National Natural Science Foundation of China
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