换一批
换一批Estrogen intervention in microvascular morphology and choline acetyltransferase expression in rat hippocampal neurons in chronic cerebral ischemia
摘要We observed dynamic changes in microvessels and a protective effect of estrogen on chronic cerebral ischemia ovariectomized rat models established through permanent occlusion of bilateral carotid arteries at 7, 14 and 21 days. The results revealed that estrogen improved microvasculature in the hippocampus of chronic cerebral ischemic rats, upregulated Bcl-2 protein expression, downregulated Bax protein expression, increased choline acetyltransferase expression in hippocampal cholinergic neurons, and suppressed hippocampal neuronal apoptosis. These findings indicate that estrogen can protect hippocampal neurons in rats with chronic cerebral ischemia.
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关键词
estrogenchronic cerebral ischemiahippocampusmicrovasculatureBcl-2Baxcholine acetyltransferaseneural regeneration
分类号
R743.3
栏目名称
DOI
10.3969/j.issn.1673-5374.2011.17.001
发布时间
2011-08-23
基金项目
Hebei Provincial Education Ministry（Z200632）
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