换一批
换一批Using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to analyze differentially expressed brain polypeptides in scrapie strain 22L-infected BALB/c mice
摘要Differentially expressed polypeptides in the brain of a BALB/c mouse model infected with scrapie strain 22L were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The results showed that 21 peptides were down-regulated, with peptides of mass-to-charge ratio 758.772 5 and mass-to-charge ratio 5 432.206 9, demonstrating the most significant decreases. These finding suggest that these peptides are candidate biomarkers and may play an important role in the pathogenesis of prion disease.
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关键词
prion diseasesmisfolded prion proteinimaging mass spectrometrypeptidesbiological markersmass spectrometry
分类号
R742.9
DOI
10.3969/j.issn.1673-5374.2011.23.007
发布时间
2011-11-14
基金项目
the National Natural Science Foundation of China（30972197;31072148）；
Science and Technology Plan Program of Jilin Province（201105038）
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