首页 > 中国神经再生研究（英文版） > Flavonoids from the stems and leaves of Scutellaria baicalensis Georgi attenuate H2O2-induced oxidative damage to rat cortical neurons

Flavonoids from the stems and leaves of Scutellaria baicalensis Georgi attenuate H2O2-induced oxidative damage to rat cortical neurons

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摘要Primary cultures of rat cortical neurons were treated with H2O2 in an in vitro model of free radical neurotoxicity. Flavonoids extracted from the stems and leaves of Scutellaria baicalensis Georgi, known as SSF, at concentrations of 18.98, 37.36 and 75.92 μg/mL, protected neurons against H2O2 injury in a dose-dependent manner. SSF increased cell survival, reduced lactate dehydrogenase release and inhibited malondialdehyde production. SSF also inhibited reductions in superoxide dismutase, glutathione peroxidase and Na+-K+-ATPase activities. These results in-dicate that SSF can protect rat cortical neurons against H2O2-induced oxidative injury.

作者单位 Key Laboratory of Traditional Chinese Medicine Research and Development of Hebei Province, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China ^[1]

关键词 flavonoids from Scutellaria baicalensis Georgi H2O2 lactate dehydrogenase superoxide dismutase malondialdehyde glutathione peroxidase Na+-K+-ATPase neural regeneration

分类号 R285.5（中药学）

栏目名称

Research and Reports

DOI 10.3969/j.issn.1673-5374.2011.27.003

发布时间 2011-11-22（万方平台首次上网日期，不代表论文的发表时间）

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