换一批Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia
摘要The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion (pMCAO), pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia (at 8 hours after pMCAO), inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data sug-gest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins.
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bilobalideaquaporinbrain edemapermanent middle cerebral artery occlusionglial fibrillary acidic proteinneural regeneration
分类号
R285.5（中药学）
栏目名称
DOI
10.3969/j.issn.1673-5374.2011.27.004
发布时间
2011-11-22（万方平台首次上网日期，不代表论文的发表时间）
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