换一批摘要Acanthopanax senticosus aqueous extract, at 10, 5 and 2.5 μg/mL, lessened hypoxia-induced PC12 cell injury. Pretreatment with the extract upregulated Bcl-2 expression, downregulated Bax expression, elevated superoxide dismutase activity, diminished malondialdehyde content, relievedCa2+ overloading, and suppressed apoptosis of PC12 cells. These effects were most pronounced at10 μg/mL. These results suggest that Acanthopanax senticosus aqueous extract protects PC12cells from hypoxia-induced injury in a dose-dependent manner.
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关键词
Acanthopanax senticosus aqueous extractPC12 cellshypoxiaoxidative stressCa2+overloadingapoptosisneural regeneration
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DOI
10.3969/j.issn.1673-5374.2011.30.003
发布时间
2011-12-15（万方平台首次上网日期，不代表论文的发表时间）
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