Influence of electroacupuncture on mitogen-activated protein kinase signal transduction in a rat model of cerebral ischemia/reperfusion

二维码有效期 120s

摘要Following electroacupuncture at Baihui (DU 20) and Dazhui (DU 14) in a rat model of cerebral ischemia/reperfusion, extracellular-signal-regulated kinase expression in cerebral cortex and corpusstriatum, serum glutathione reductase, glutathione peroxidase activity, and serum glutathionecontent were elevated, and neurobehavioral scores improved. However, these effects were antagonized by mitogen-activated protein kinase inhibitor PD98059. Results indicated that electroacupuncturereversed free radical chain reactions and oxidative stress injury caused by cerebralischemia/reperfusion, thereby providing neuroprotection. This process could correlate with the mitogen-activated protein kinase signal transduction pathway.

关键词 anti-oxidative stress cerebral ischemia/reperfusion electroacupuncture mitogen-activated protein kinase pathway signal transduction

分类号 R322.8

栏目名称 Research and Reports

DOI 10.3969/j.issn.1673-5374.2011.30.008

发布时间 2011-12-15

基金项目

the Major Program of National Natural Science Foundation of China the National Natural Science Foundation of China the Natural Science Foundation of Jiangsu Province

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交