Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system

二维码有效期 120s

摘要A number of studies have confirmed the existence of tissue-type plasminogen activator-independent roles of neuroserpin, a member of the serine protease inhibitor superfamily. In this review article, we aim to clarify this role. These unique roles of neuroserpin are involved in its neuroprotective effect during ischemic brain injury, its regulation of tumorigenesis, and the mediation of emotion and cognition through the inhibition of urokinase-type plasminogen activator and fibrinolysin, modification of Th cells, reducing plaque formation, promoting process growth and intracellular adhesion, and altering the expression of cadherin and nuclear factor kappa B.

作者单位 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China;Laboratory of Early Developmental and Injuries, West China Institut ^[1]

关键词 neuroserpin tissue-type plasminogen activator serpin cerebral ischemia tumor familial encephalopathy with neuroserpin inclusion bodies

分类号 R322.8

栏目名称 Reviews

DOI 10.3969/j.issn.1673-5374.2012.02.012

发布时间 2012-02-17

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交