换一批Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats
摘要Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.
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关键词
curcumingp120 V3 loophippocampal neuronsmitochondrial membrane potentialcaspase-3human immunodeficiency virus-associated neurocognitive functionneural regeneration
分类号
Q189（神经科学）
栏目名称
DOI
10.3969/j.issn.1673-5374.2012.03.002
发布时间
2012-02-17（万方平台首次上网日期，不代表论文的发表时间）
基金项目
This study was supported by the Natural Science Foundation of Guangdong Province,（No.9151040701000,061050246）
the Science and Technology Project of Guangdong Province,（No.2010B030700016）
the Science and Technology Project of Guangzhou,（No.2010Y1-C291）
the National Natural Science Foundation of China,（No.81171134）
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