换一批Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus
摘要In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.
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关键词
sericintype 2 diabetes mellitushippocampusapoptosisAkt signal transduction pathwayneural regeneration
分类号
Q189（神经科学）
栏目名称
DOI
10.3969/j.issn.1673-5374.2012.03.007
发布时间
2012-02-17（万方平台首次上网日期，不代表论文的发表时间）
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