Rabs and axonal regeneration

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摘要Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the ac-tivity of a number of Rab GTPases might act to restrict axonal regeneration. A loss of Rab27b, in particular, is shown to enhance axonal regeneration in vitro, as well as in C. elegans and mouse central nervous system injury models in vivo. Possible mechanisms underlying this new finding, which has important academic and translational implication, are discussed.

作者单位 Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore ^[1] Department of Biochemistry, Yong Loo Lin School of Medicine, National University Health System, Singapore;National University of Singapore Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore ^[2]

关键词 Arf Rab Rab27b axon regeneration axonal transport cortical neurons central nervous system injury membrane trafficking Myosin-V

栏目名称 REVIEWS

DOI 10.4103/1673-5374.247422

发布时间 2019-01-25

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