换一批摘要The locus coeruleus is a pontine nucleus that produces much of the brain’s norepinephrine. Despite its small size, the locus coeruleus is critical for a myriad of functions and is involved in many neurodegener-ative and neuropsychiatric disorders. In this review, we discuss the physiology and anatomy of the locus coeruleus system and focus on norepinephrine’s role in synaptic plasticity. We highlight Parkinson’s disease as a disorder with motor and neuropsychiatric symptoms that may be understood as aberrations in the normal functions of locus coeruleus.
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关键词
catecholaminescopperneurodegenerative diseasesneuromodulationneuronal circuitsneuropsychiatric symptomsnoradrenalinesynaptic plasticity
栏目名称
DOI
10.4103/1673-5374.270297
发布时间
2019-12-17（万方平台首次上网日期，不代表论文的发表时间）
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