Convergence of human and veterinary medicine:leveraging canine naturally occurring neurological disorders to develop regenerative treatments
摘要In recent years,large animal models of naturally occurring diseases have become increasingly studied,with the rationale that their disease attributes may better recapitulate the pathological features of corresponding human diseases as compared to induced disease models(Hoffman and Dow,2016).Of the available naturally occurring disease models,the canine is increasingly recognized as a valuable pre-clinical animal model in translational medicine for numerous human diseases,including cancer,respiratory disease,and inflammatory disease(Kol et al.,2015;Hoffman and Dow,2016).
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