Etiology matters:genetic and acquired prion diseases engage different mechanisms at a presymptomatic stage
摘要One of the most enigmatic problems in biomedical research surrounds the phenomenon that neurodegenerative diseases target specific cell types and brain regions.This is difficult to explain because the proteins that cause them are widely expressed,often highest in resistant regions.This mystery is further complicated by the fact that some disease-causing proteins are associated with multiple diseases.
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