换一批摘要Misfolding of proteins as well as their aggregation is a major driver of age-related neurodegenerative diseases.Hence,cells have evolved sophisticated protein quality control mechanisms.Mainly the ubiquitin-proteasome-system(UPS)and the autophagosome-lysosome-system,specifically a macroautophagy pathway called"aggrephagy",govern the disposal of aggregates.
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