换一批Mitochondria-cGAS-STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration
摘要The word"senescence"comes from the Latin senescens,meaning"to begin to age",and is characterized by a long-lasting but reversible block in proliferation,resulting from stress-induced cell cycle arrest of previously replication-competent cells.Many stress situations lead to senescence,including telomere shortening,genotoxic stress,oncogene-and oxidative-induced stress,and mitochondrial dysfunction(Mico et al.,2021).It is also characterized by a proinflammatory senescence-associated secretory phenotype(SASP)that potentiates chronic low-grade inflammation and inflammaging-associated dysfunction,resulting in loss of tissue function and health(Figure 1;Mico et al.,2021).
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