Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

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摘要Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the cell.Nevertheless,this organelle is also involved in a plethora of different cellular functions such as calcium(Ca2+)homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,and β-oxidation of fatty acids.

作者 Laetitia Aubry ^[1] Timothy Barrett ^[2] Sovan Sarkar ^[3] 学术成果认领

作者单位 I-STEM,CECS,Corbeil-Essonnes,France;Université Paris-Saclay,Université d'Evry,INSERM,I-STEM,UMR861,Corbeil-Essonnes,France ^[1] Institute of Cancer and Genomic Sciences,Institute of Biomedical Research,College of Medical and Dental Sciences,University of Birmingham,Edgbaston,Birmingham,UK;Department of Endocrinology,Birmingham Women's and Children's Hospital,Steelhouse Lane,Birmingham,UK ^[2] Institute of Cancer and Genomic Sciences,Institute of Biomedical Research,College of Medical and Dental Sciences,University of Birmingham,Edgbaston,Birmingham,UK ^[3]

栏目名称 Perspectives

DOI 10.4103/NRR.NRR-D-23-02021

发布时间 2024-12-26

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