换一批Adipose tissue-brain crosstalk in comorbid obesity and traumatic brain injury:Insights into mechanisms
摘要Obese individuals who subsequently sustain a traumatic brain injury(TBI)exhibit worsened outcomes including longer periods of rehabilitation(Eagle et al.,2023).In obese individuals,prolonged symptomology is associated with increased levels of circulatory pro-inflammatory markers up to 1 year post-TBI(Eagle et al.,2023).Despite this,the mechanisms driving worsened outcomes remain poorly understood.Expanding our understanding of the underlying mechanisms driving obesity-induced exacerbations of TBI deficits is important at a fundamental physiological level and for the identification of novel therapeutic approaches for TBI patients with underlying metabolic dysfunction.
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