摘要Loss of immune tolerance to central nervous system(CNS)antigens lies at the heart of multiple sclerosis(MS),the most common chronic autoimmune disease of the CNS.MS affects nearly 2 million people worldwide and is characterized by focal areas of demyelination,inflammation,axonal injury,and neurodegeneration(Bronge et al.,2022;Magliozzi et al.,2023).The condition leads to symptoms such as numbness,muscle weakness,fatigue,visual impairment,and cognitive decline(Magliozzi et al.,2023).Although autoreactive T cells are considered to be primed in peripheral lymphoid tissues initially,it is the local reactivation of these T cells upon encountering CNS antigens that critically drives the inflammatory response within the CNS(Koch et al.,2022).