换一批摘要Progranulin(PGRN),encoded by the GRN gene,is a secreted glycoprotein that undergoes proteolytic cleavage to generate individual granulin peptides(granulin A-G)capable of exerting distinct biological functions.PGRN is widely expressed in multiple tissues,including the central nervous and immune systems.Within the central nervous system,PGRN is highly expressed in the hippocampus,cerebral cortex,and hypothalamus,and has been detected in various neuronal subtypes,including Purkinje cells and motor neurons,where it plays a crucial role in neuronal functions such as neurite outgrowth and synaptic plasticity.
更多相关知识
- 浏览0
- 被引0
- 下载0
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
