换一批摘要Surfeit 4(Surf 4),one of the identified housekeeping genes,was previously thought to encode a transmembrane protein that acts as a cargo receptor to maintain basic cellular functions.In recent years,Surf 4 gene is overexpressed in some types of cancer,involved in the exosome signaling pathway in gastrointestinal stromal tumors,and played the role of an oncogene in ovarian cancer stem cells.In this paper,we review the characteristics and protein localization of Surf 4 gene,as well as its possible physiological functions and pathogenesis in various diseases and cancers,expecting to discuss its clinical application value.
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