摘要Objective:To observe the effect of moderate oxygen preconditioning on pulmonary function and electrophysiological properties of hippocampal neurons in rats with lung cancer.Methods:By establishing a lung cancer surgery model in rats,the experimental animals were randomly divided into model group,surgery group,oxygen treatment group A,oxygen treatment group B,and oxygen treatment group C.Lung cancer group was not treated,lung cancer surgery group underwent surgery to remove lung tissue,oxygen treatment group A received oxygen pre-treatment at a concentration of 1-3 L/min,oxygen treatment group B received oxygen pre-treatment at a concentration of 4-5 L/min,and oxygen treatment group C received oxygen pre-treatment at a concentration of 6-8 L/min.After operation,Morris water maze behavior was observed,lung function indicators were measured by lung function test,and the amplitude and frequency of micro-excitatory postsynaptic current of hippocampal neurons in rats were detected by electrophysiological membrane clamp.Results:Lung cancer surgery would have an effect on the spatial memory in lung cancer rats,and the spatial memory ability of oxygen-treated group A,group B and group C was improved compared with that of the surgery group.FEV 0.3(forced expiratory capacity at 0.3 s)and FVC(forced vital capacity)in the oxygen-treated group B were significantly higher than those in the model group,in which the improvement of FEV 0.3 and FVC reached(3.32±0.42)mL and(3.79±0.82)mL,respectively.The FEV 0.3/FVC ratio of 87.04±1.44 in oxygen-treated group B was higher than that of the model group and surgery group.The post-synaptic current frequency(3.73±0.27)Hz and post-synaptic current(13.74±0.26)pA of oxygen-treated group B were also significantly increased compared to other groups(P<0.05).Conclusion:Moderate oxygen preconditioning,especially at a concentration of 4-5 L/min,can exert protective effects on lung and hippocampal neurons in a rat model of lung cancer surgery,helping to improve lung function and alleviate the electrophysiological damage of hippocampal neurons.