摘要目的 利用光学相干断层扫描仪(optical coherence tomography,OCT)测量垂体瘤患者视盘周围视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度,分析其RNFL厚度改变的区域及与视野损害的相关性.方法 采用OCT Fast RNFL thick 3.4程序对正常人30例(56只眼),垂体瘤视野正常者25例(50只眼),垂体瘤颞侧视野偏盲者35例(56只眼)进行视盘周围RNFL厚度测量,计算RNFL厚度平均值及鼻、颞、上、下各区域的RNFL厚度,对各参数行组内和组间比较.结果 垂体瘤视野正常组与正常组比较RNFL厚度平均值及鼻、上和下方RNFL厚度差异均无统计学意义(P＞0.05),颞侧RNFL较正常组增厚,差异具有统计学意义(P＜0.05);垂体瘤视野偏盲组与垂体瘤视野正常组及正常组比较RNFL厚度平均值及各区域RNFL厚度均明显变薄,差异均有统计学意义(P＜0.05).垂体瘤视野正常组及视野偏盲组颞侧RNFL厚度均大于鼻侧,差异具有统计学意义(P＜0.05).结论 垂体瘤患者RNFL厚度变化与视野缺损有一致性.OCT可作为判断垂体瘤患者视功能预后的重要指标.

abstractsObjective To measure the thickness of retinal nerve fiber layer (RNFL) surrounding of optic disc using optical coherence tomography (OCT) to assess changes of RNFL thickness in patients of pituitary tumor and to analyze the correlation with the damage of visual field. Methods The thickness of RNFL surrounding of optic disc were measured in 30 normal persons (56 eyes), 25 patients (50 eyes) of pituitary tumor without damage of visual field and 35 patients (56 eyes) of pituitary tumor with half-blindness of temporal visual field using the program of OCT Fast RNFL thick 3.4. The mean value of RNFL thickness and the RNFL thickness in nasal, temporal, superior and inferior area were measured and compared in or between the groups.Results There were no significant difference in mean value of RNFL and which in nasal, superior and inferior area between the patients of pituitary tumor without damage of visual field and normal group (P ＞0.05), while the temporal RNFL was thicker than the normal (P ＜0.05). The mean value of RNFL and which in each area were thinner significantly in the patients of pituitary tumor with half-blindness of temporal visual field compared with those without visual field damaging and normal group (P ＜0.05). The RNFL in temporal area was thicker than which in nasal area in the patients of pituitary tumor with or without visual field damaging (P ＜0.05). Conclusions There is good correlation between RNFL thickness and visual field damaging in the patients of pituitary tumor. OCT can be used to predict the outcome of the visual function of the pituitary tumor patients.