摘要目的 评估24h眼压测量在正常眼压性青光眼中的意义,以更好地指导临床应用.方法 于2008年1月至2011年2月正常眼压性青光眼(NTG)患者共86例(86只眼)入选本研究,应用非接触眼压计自清晨8:00开始至第二天清晨8:00,每两小时测量一次,共12次；采用A型超声波角膜测厚仪对中央角膜厚度进行测定.结果 所有86只眼的24h眼压测量值中,29只眼(33.7％)在正常范围内且昼夜眼压波动小于5 mm Hg,而57只眼(66.3％)出现异常.所有患者昼夜眼压曲线中眼压低谷值为(13.78±1.39) mm Hg眼压高峰值为(18.52±1.81) mm Hg,分别出现于18:00～20:00和夜间2:00.根据24 h最高眼压是否高于21 mm Hg分为高眼压组和低眼压组,两组年龄差异显著有统计学意义,而中央角膜厚度无明显差异.结论 24 h眼压测量应作为正常眼压性青光眼患者诊断的常规检查,能提高夜间眼压高峰及昼夜波动过大的检出率,避免漏诊误诊的发生.

abstractsObjective To evaluate the effect of 24-hour IOP measurement in the suspects of normal-tension glaucoma. Methods Eight-six patients (86 eyes)with normal tension glaucoma (NTG)were enrolled in the study from December 2008 to December 2010.Non-contact tonometer was used to measure the IOP once every two hours from 8:00 AM to the next 8:00 AM,with a total of 12 times a day.Central comeal thickness was also measured.Results The IOPs of 29 eyes (33.7％) were within normal range and the diurnal fluctuations of IOP were no more than 5mmHg,while the IOPs of the other 57 eyes (66.3％) were abnormal.The average lowest IOP of all the patients was 13.78 ± 1.39mmHg and the highest was 18.52 ± 1.81mmHg,which appeared during 6:00 PM to 8:00 PM and 2:00 AM,respectively.The patients were divided into two groups according to 24-hour peak IOP (group A＞21mmHg,group B＜21mmHg).There was an age significant difference between the two groups,but no significant difference in central comeal thickness. Condusion The 24-hour lOP measurement should be a routine examination in patients with NTG,which can increase the the detective rate of nocturnal IOP peak and diurnal fluctuation,and thus prevent the occurrence of misdiagnosis.