摘要目的 观察渐进多焦点眼镜联合消旋山莨菪碱滴眼液对减缓青少年中低度近视进展的疗效及安全性.方法 临床病例对照研究.对2010年6月至2011年3月在嵊州市医院眼科诊治的156例中低度近视青少年(8～16周岁)按检查时间随机分成4组,A组为单焦点镜片组；B组为单焦点镜片联合消旋山莨菪碱滴眼液组；C组为渐进多焦点组；D组为渐进多焦点联合消旋山莨菪碱组.于配镜后6月、12月、18月复查屈光度、眼压、眼球前后径、角膜曲率、水平隐斜度,记录患者治疗感受及不良反应.结果 治疗18个月,各组近视屈光度、眼球前后径均有不同程度的增长.各组治疗前后眼压、角膜平均曲率、水平隐斜度差异均无统计学意义(P＞0.05).渐进多焦点眼镜联合消旋山莨菪碱滴眼液组青少年近视屈光度及眼球前后径的增长值不但小于单焦点镜片组,而且小于单用渐进多焦点眼镜组和单焦点镜片联合消旋山莨菪碱滴眼液组,差异有统计学意义(P＜0.05),且未见相关治疗不良反应.结论 渐进多焦点眼镜联合消旋山莨菪碱滴眼液能安全有效地减缓大多数青少年中低度近视的进展.

abstractsObjective To investigate the effect of progressive addition lenses combined with raceanisodamine on myopia in Chinese juvenile children.Methods A total of 156 case (312 eyes) of 8-16 years-old patients with myopia range from-0.75D ～-5.00D were randomly divided into four groups,in which group A was only treated by monofocal lenses,group B was treated by monofocal lenses and raceanisodamine eye drops,group C was only treated by progressive addition lenses,group D was treated by progressive addition lenses and raceanisodamine eye drops.Refraction,corneal curvature,axial length,intraocular pressure,horizontal phoria was measured in each patient.All the subjects were followed up every 6 months for a period of 18 months.Results After 18 months,the refiaction,anteroposterior axis of eyeball of 4 groups significantly increased comparing with the baseline examination,and corneal curvature,intraocular pressure,horizontal phoria had no significant differences.The increase of refraction,axial length in group D (treated by progressive addition lenses and raceanisodamine eye drops) was significantly less than group A (only treated by monofocal lenses) group B (treated by monofocal lenses and raceanisodamine eye drops) and group C (only treated by progressive addition lenses).There were no other complaints and complications in all subjects.Conclusions The progression of the myopia can be controlled safely and effectively with progressive addition lenses combined with raceanisodamine for most of myopia in Chinese juvenile children.