摘要目的 观察泪道插管联合丝裂霉素C和妥布霉素地塞米松眼膏治疗泪道阻塞疗效.方法 将78只眼泪道阻塞患者随机分为两组:A组40只眼,行丝裂霉素+妥布霉素地塞米松眼膏+泪道插管；B组38只眼(对照组),行单纯性泪道插管,观察两组疗效,A组首先向泪道注入浓度为0.2 mg/ml的丝裂霉素C 0.2 ml,5 rmin后彻底冲洗,随后向泪道注满妥布霉素地塞米松眼膏,B组行单纯性泪道插管.结果 随访6～9个月,术后1、3个月的A组治愈率均为100％,B组分别为89.5％、81.5％,6、9个月的A组治愈率均为95％,B组分别为73.7％、71.1％,两组差异有统计学意义(P＜0.05),A组显著高于B组.结论 泪道插管术中联合丝裂霉素C和妥布霉素地塞米松眼膏可明显提高术后长期治愈率.

abstractsObjective To observe the lacrimal intubation with mitomycin and TobraDex Ophthalmic ointment (TDO) in the treatment of lacrimal passage obstruction.Methods Senventy-eight eyes with obstruction of lacrimal passage were randomly divided into group A (40 eyes,MMC+TDO)and group B (38 eyes,control group).In group A,40 eyes firstly applied 0.2mg/ml MMC,washed thoroughly after 5 minutes,then filled up TobraDex Ophthalmic ointment.In group B,38 eyes only conducted Lacrimal duct intubation.Results All patients were followed up for 6-9 months.After 1 month and 3 months treatment,the healing rates of group A were 100％,group B 89.5％,81.5％respectively; after 3 and 9 months,the healing rates of group A were 95％,group B was 73.7％,71.1％ respectively,there was a great significantly difference between the two groups (P ＜0.05),group A was significantly higher than that of B group.Conclusions Mitomycin C combined with TobraDex Ophthalmic ointment can significantly improve the healing rate on patients of LDCL in long term.