摘要目的 观察阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)与非阻塞性睡眠呼吸暂停综合征患者眼底神经纤维层厚度的变化.方法 临床病例对照研究.对2013年12月至2014年3月在重庆医科大学附属第一医院耳鼻喉科就诊的45例OSAHS患者同年龄、性别、无基础疾病的45例为对照组分别进睡眠呼吸监测、RNFL厚度、眼内压的测量,测量结果进行统计学分析.结果 OSAHS组患者与非OSAHS组的年龄、性别、眼压无统计学差异;OSAHS组较对照组的平均RNFL厚度(P＜0.01,t=2.8501)、鼻上RNFL厚度NS (P ＜0.001,t=3.4987)、鼻下RNFL厚度NI (P ＜0.05,t=2.5540)、颞上RNFL厚度TS (P ＜0.001,t=3.5546)、颞下RNFL厚度TI (P ＜0.05,t=2.5845)均明显变薄,差异有统计学意义.颞测RNFL厚度T(P ＞0.05,t=0.4174)、鼻测RNFL厚度N(P ＞0.05,t=1.9579)其差异无统计学意义.结论 OSAHS患者的平均、颞上、颞下、鼻上、鼻下方视网膜神经纤维层较非OSAHS患者变薄,OSAHS可能是青光眼、缺血性视神经病变的另一高危因素,应积极观察OSAHS患者的眼部表现.

abstractsObjective To investigate changes in retinal nerve fiber layer (RNFL) in patients with obstructive sleep apnea syndrome (OSAHS).Methods In this study,45 patients with OSAHS were included based on apnea hypopnea index (AHI ≥5).The control group was matched for age,gender,best-corrected visual acuity and body mass index.Retinal nerve fiber layer (RNFL) parameters,intraocular pressure were compared between two groups.Results There was a significantly difference between groups in RNFL (average P ＜0.01;Nasal superior quadrant,NS P ＜0.01;Nasal inferior quadrant,NI P ＜0.05;Superior Temporal quadrant,TS P ＜0.01;temporal inferior quadrant,TI P ＜0.05),and there was no significantly difference between groups in Temporal quadrant and Nasal quadrant.No significantly difference in best-corrected visual acuity,intraocular pressure,age,and gender between two groups.Conclusions The retinal nerve fiber layer of OSAHS (average,nasal superior quadrant,nasal inferior quadrant,superior temporal quadrant,and temporal inferior quadrant) is thinner than those of non-OSAHS.This may be another high risk factor for glaucoma or Non-arteritic ischemic optic neuropathy.