摘要目的 探索倍频视野检查法(frequency-doubling technology perimetry,FDP)对视野前期开角型青光眼(open-angle glaucoma,OAG)在将来标准自动视野检查法(standard automated perimetry,SAP)上出现视野异常的风险预测能力.方法 前瞻性队列研究.对单眼SAP视野异常(Octopus,G2程序)OAG患者视野正常眼进行基线FDP-N30程序检测,将FDP的19个刺激区匹配至SAP视野的53个测试点,之后连续8年SAP视野随访,最终计算FDP刺激区的异常转化为将来SAP相应区域视野异常的相对危险度(relative risk,RR).结果 48例患者完成了8年随访.基线时,912个FDP刺激区中有21％ (196/912)检测出异常,其中26％ (51/196)的异常刺激区在4～90个月转化为SAP相应区域的视野异常.FDP刺激区的异常转化为将来SAP相应区域异常的RR为5.50 (95％置信区间3.53～8.58,p＜0.001).结论 在视野前期OAG中,FDP可以在一定程度上对将来SAP视野的异常进行准确的风险预测.

abstractsObjective To explore the potential of frequency-doubling technology perimetry (FDP) for predicting the risk of future visual field loss on standard automated perimetry (SAP) for preperimetric openangle glaucoma(OAG).Methods A prospective cohort study.OAG patients with unilateral field loss detected by SAP (Octopus,G2 program) were examined with the FDP N-30 threshold program (Humphrey Instruments) at baseline.53 of the SAP test points were matched to the 19 of FDP sectors as SAP-on-FDP sectors.Visual field examinations were followed by a series of SAP examinations for the perimetrically normal eyes administered over 8 years.The relative risk (RR) of subsequent SAP abnormality corresponding to FDP abnormal sectors in perimetrically normal eyes of participants at baseline was calculated finally.Results Forty-eight perimetrically normal eyes of 48 participants had complete data and a qualifying follow-up.At baseline,there were 912 FDP sectors in the 48 eyes with normal SAP results,from which 21％ (196/912) were abnormal.During the 8-year-follow-up,26％(51/196) for FDP abnormal sectors developed an SAP abnormality in the SAP-on-FDP sector in 4 to 90 months after baseline,and the RR of subsequent SAP abnormality corresponding to abnormal FDP sectors was 5.50 (95％ confidence interval,3.53～8.58;P ＜0.001).Conclusions In preperimetric OAG,FDP could exactly predict the risk of future visual field loss on SAP to some extent.