摘要Drimane-type sesquiterpenoids are widely distributed in fungi.From the ethyl acetate extract of the earwig-derived As-pergillus sp.NF2396,seven new drimane-type sesquiterpenoids,named drimanenoids A-G(1-7),were isolated.Their structures were elucidated by diverse spectroscopic analysis including high-resolution ESI-MS,one-and two-dimensional NMR spectroscopy.Drim-anenoids A-F(1-6)are new members of drimane-type sesquiterpenoid esterified with unsaturated fatty acid side chain at C-6.Drim-anenoids C(3),D(4)and F(6)showed antibacterial activity against five types of bacteria with different inhibition diameters.Drim-anenoid D(4)exhibited moderate cytotoxicity against human myelogenous leukemia cell line K562 with an IC50 value of 12.88±0.11 μmol·L-1.
作者单位State Key Laboratory of Pharmaceutical Biotechnology,Institute of Functional Biomolecules,School of Life Sciences,Nanjing University,Nanjing 210093,China[1]Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan Province,Hainan Institute for Tropical Agri-cultural Resources,Haikou 571101,China;Hainan Academy of Ocean and Fisheries Sciences,Hainan Tropical Ocean University,Haikou 571126,China[2]Hainan Academy of Ocean and Fisheries Sciences,Hainan Tropical Ocean University,Haikou 571126,China[3]Hainan Key Laboratory of Tropical Microbe Resources,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China;Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan Province,Hainan Institute for Tropical Agri-cultural Resources,Haikou 571101,China[4]
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