摘要In the current study,tea saponin,identified as the primary bioactive constituent in seed pomace of Camellia oleifera Abel.,was meticulously extracted and hydrolyzed to yield five known sapogenins:16-O-tiglogycamelliagnin B(a),camelliagnin A(b),16-O-angeloybarringtogenol C(c),theasapogenol E(d),theasapogenol F(e).Subsequent biotransformation of compound a facilit-ated the isolation of six novel metabolites(a1-a6).The anti-inflammatory potential of these compounds was assessed using pathogen-associated molecular patterns(PAMPs)and damage-associated molecular patterns molecules(DAMPs)-mediated cellular inflamma-tion models.Notably,compounds b and a2 demonstrated significant inhibitory effects on both lipopolysaccharide(LPS)and high-mo-bility group box 1(HMGB 1)-induced inflammation,surpassing the efficacy of the standard anti-inflammatory agent,carbenoxolone.Conversely,compounds d,a3,and a6 selectivity targeted endogenous HMGB 1-induced inflammation,showcasing a pronounced spe-cificity.These results underscore the therapeutic promise of C.oleifera seed pomace-derived compounds as potent agents for the man-agement of inflammatory diseases triggered by infections and tissue damage.