Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge
摘要With the awarding of the 2015 Nobel Prize in Physiology or Medicine to Chinese pharmacologist Tu Youyou,and the significant contributions of traditional Chinese medicine(TCM)for coronavirus disease 2019(COVID-19),TCM has garnered increasing attention and interest globally.Although advanced research progress has been made in the efficacy re-search,mechanism elucidation and target prediction of TCM in recent years[1],there is still no generic way to understand TCM and apply them to clinical practice from the perspect-ive of modern biomedical science.Recently,Gan et al.estab-lished a network medicine framework centered on protein in-teractome(also referred to as protein-protein interaction net-work)to indicate the probability of co-occurrence of symp-toms and the effectiveness of herbs in treating specific symp-toms by analyzing network topology relationships[2].
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